Therapy-related Myeloid Leukemia With the Translocation t(8;19)(p11;q13) Leading to a <i>KAT6A-LEUTX</i> Fusion Gene

Background/aim The chromosome translocation t(8;19)(p11;q13) has been reported in only six acute myeloid leukemia (AML) patients. We here present the genetic and clinical features of seventh AML case with this aberration. Materials methods Cytogenetic molecular investigations were performed on leukemic bone marrow cells from a patient therapy-related AML. Results A was found leading to an in-frame fusion exon 16 lysine acetyltransferase 6A gene (KAT6A) 8p11 2 leucine twenty homeobox (LEUTX) 19q13 resulting expression otherwise silent LEUTX cells. KAT6A-LEUTX protein is predicted act as histone at its amino-terminal-KAT6A moiety but transcription factor LEUTX-carboxyl-terminal moiety. Conclusion second AML, third overall, which both result, gene, are described. t(8;19)(p11;q13)/KAT6A-LEUTX deregulates induces leukemogenesis.